On November in 1918, during the restructuring of the second government of the first Republic of Armenia, Ministry of Welfare has been established, which on 8 of April in 1919 it was renamed Ministry of Welfare and Labor.

On 8 of January in 1920 the ministry was renamed the ministry of Welfare and Rehabilitation which had the following sections: an orphanage, immigration, organization of work, medical-sanitary, labor protection, architecture, construction.

After the establishment of the Soviet Regime, on 22 of December in 1920, by 17th decree of ASSR Revolution Committee, was organized The National Commissariat of Health of Armenia.

The National Health Commissars of the Soviet Socialistic Republic of Armenia were:

1920-1922. Sarkis Hambardzumyan
1922-1925 . Simeon Lazarev
1925-1927 . Garegin Gardashyan
1927-1937. Gevorg Ghevondyan
1937-1940. Babken Astvatsatryan
1940-1945. Stepan Chshmarityan.

In 1946 The National Commissariat of Health of Armenia was reorganized as the Ministry of Health of the Soviet Socialistic Republic of Armenia, in which structure were included preventive care, mother and child preventive care sanitary-epidemiological and 4th departments, units of scientific, human resources, medical statistics, administrative-economic, delivery.

The Ministers of the Ministry of Health of the Soviet Socialistic Republic of Armenia were:

1945-1949. Gevorg Ghevondyan
1949-1960. Armenak Khrimyan
1960-1975 Zakhari Narimanov
1975-1989 Emil Gabrielyan
1989-1990 Artashes Aznauryan

As a result of the Referendum held on September 21, 1991 The Ministry of Health of the Soviet Socialistic Republic of Armenia was proclaimed Independent Republic of Armenia.

The Ministers of Health of the Republic of Armenia were:

1990-1991. Mihran Nazaretyan
1991-1997. Ara Babloyan
1997-1998. Gagik Stamboltsyan
1998-2000. Hayk Nikoghosyan
2000-2000 Ararat Mkrtchyan (The Minister of Health and Welfare)
2000-2003. Ararat Mkrtchyan (The Minister of Health)
2003-2007. Norayr Davidyan
2007-2012. Harutyun Kushkyan
2012- 2014. Derenik Dumanyan
2014 – 2016. Armen Muradyan
2016 – 2018. Levon Altunyan
2018 – 2021. Arsen Torosyan

Since 18 January, 2021 to present – Anahit Avanesyan